Alexis Thomson and Alexander Miles - Manual of Surgery

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Cellulitis of the _sole of the foot_ may follow whitlow of the toes.

In the _region of the ankle_ cellulitis is not common; but _around the
knee_ it frequently occurs in relation to the prepatellar bursa and to
the popliteal lymph glands, and may endanger the knee-joint. It is also
met with in the _groin_ following on inflammation and suppuration of the
inguinal glands, and cases are recorded in which the sloughing process
has implicated the femoral vessels and led to secondary haemorrhage.

Cellulitis of the scalp, orbit, neck, pelvis, and perineum will be
considered with the diseases of these regions.

CHRONIC SUPPURATION

While it is true that a chronic pyogenic abscess is sometimes met
with--for example, in the breast and in the marrow of long bones--in the
great majority of instances the formation of a chronic or cold abscess
is the result of the action of the tubercle bacillus. It is therefore
more convenient to study this form of suppuration with tuberculosis
(p. 139).

SINUS AND FISTULA

#Sinus.#--A sinus is a track leading from a focus of suppuration to a
cutaneous or mucous surface. It usually represents the path by which the
discharge escapes from an abscess cavity that has been prevented from
closing completely, either from mechanical causes or from the persistent
formation of discharge which must find an exit. A sinus is lined by
granulation tissue, and when it is of long standing the opening may be
dragged below the level of the surrounding skin by contraction of the
scar tissue around it. As a sinus will persist until the obstacle to
closure of the original abscess is removed, it is necessary that this
should be sought for. It may be a foreign body, such as a piece of dead
bone, an infected ligature, or a bullet, acting mechanically or by
keeping up discharge, and if the body is removed the sinus usually
heals. The presence of a foreign body is often suggested by a mass of
redundant granulations at the mouth of the sinus. If a sinus passes
through a muscle, the repeated contractions tend to prevent healing
until the muscle is kept at rest by a splint, or put out of action by
division of its fibres. The sinuses associated with empyema are
prevented from healing by the rigidity of the chest wall, and will only
close after an operation which admits of the cavity being obliterated.
In any case it is necessary to disinfect the track, and, it may be, to
remove the unhealthy granulations lining it, by means of the sharp
spoon, or to excise it bodily. To encourage healing from the bottom the
cavity should be packed with bismuth or iodoform gauze. The healing of
long and tortuous sinuses is often hastened by the injection of Beck's
bismuth paste (p. 145). If disfigurement is likely to follow from
cicatricial contraction--for example, in a sinus over the lower jaw
associated with a carious tooth--the sinus should be excised and the raw
surfaces approximated with stitches.

The _tuberculous sinus_ is described under Tuberculosis.

A #fistula# is an abnormal canal passing from a mucous surface to the
skin or to another mucous surface. Fistulae resulting from suppuration
usually occur near the natural openings of mucous canals--for example,
on the cheek, as a salivary fistula; beside the inner angle of the eye,
as a lacrymal fistula; near the ear, as a mastoid fistula; or close to
the anus, as a fistula-in-ano. Intestinal fistulae are sometimes met with
in the abdominal wall after strangulated hernia, operations for
appendicitis, tuberculous peritonitis, and other conditions. In the
perineum, fistulae frequently complicate stricture of the urethra.

Fistulae also occur between the bladder and vagina (_vesico-vaginal
fistula_), or between the bladder and the rectum (_recto-vesical
fistula_).

The _treatment_ of these various forms of fistula will be described in
the sections dealing with the regions in which they occur.

_Congenital fistulae_, such as occur in the neck from imperfect closure
of branchial clefts, or in the abdomen from unobliterated foetal ducts
such as the urachus or Meckel's diverticulum, will be described in their
proper places.

CONSTITUTIONAL MANIFESTATIONS OF PYOGENIC INFECTION

We have here to consider under the terms Sapraemia, Septicaemia, and
Pyaemia certain general effects of pyogenic infection, which, although
their clinical manifestations may vary, are all associated with the
action of the same forms of bacteria. They may occur separately or in
combination, or one may follow on and merge into another.

#Sapraemia#, or septic intoxication, is the name applied to a form of
poisoning resulting from the absorption into the blood of the toxic
products of pyogenic bacteria. These products, which are of the nature
of alkaloids, act immediately on their entrance into the circulation,
and produce effects in direct proportion to the amount absorbed. As the
toxins are gradually eliminated from the body the symptoms abate, and if
no more are introduced they disappear. Sapraemia in these respects,
therefore, is comparable to poisoning by any other form of alkaloid,
such as strychnin or morphin.

_Clinical Features._--The symptoms of sapraemia seldom manifest
themselves within twenty-four hours of an operation or injury, because
it takes some time for the bacteria to produce a sufficient dose of
their poisons. The onset of the condition is marked by a feeling of
chilliness, sometimes amounting to a rigor, and a rise of temperature to
102, 103, or 104 F., with morning remissions (Fig. 10). The heart's
action is markedly depressed, and the pulse is soft and compressible.
The appetite is lost, the tongue dry and covered with a thin
brownish-red fur, so that it has the appearance of "dried beef." The
urine is scanty and loaded with urates. In severe cases diarrhoea and
vomiting of dark coffee-ground material are often prominent features.
Death is usually impending when the skin becomes cold and clammy, the
mucous membranes livid, the pulse feeble and fluttering, the discharges
involuntary, and when a low form of muttering delirium is present.

[Illustration: FIG. 10.--Charts of Acute sapraemia from (a) case of
crushed foot, and (b) case of incomplete abortion.]

A local form of septic infection is always present--it may be an
abscess, an infected compound fracture, or an infection of the cavity of
the uterus, for example, from a retained portion of placenta.

_Treatment._--The first indication is the immediate and complete removal
of the infected material. The wound must be freely opened, all
blood-clot, discharge, or necrosed tissue removed, and the area
disinfected by washing with sterilised salt solution, peroxide of
hydrogen, or eusol. Stronger lotions are to be avoided as being likely
to depress the tissues, and so interfere with protective phagocytosis.
On account of its power of neutralising toxins, iodoform is useful in
these cases, and is best employed by packing the wound with iodoform
gauze, and treating it by the open method, if this is possible.

The general treatment is carried out on the same lines as for other
infective conditions.

#Chronic sapraemia or Hectic Fever.#--Hectic fever differs from acute
sapraemia merely in degree. It usually occurs in connection with
tuberculous conditions, such as bone or joint disease, psoas abscess, or
empyema, which have opened externally, and have thereby become infected
with pyogenic organisms. It is gradual in its development, and is of a
mild type throughout.

[Illustration: FIG. 11.--Chart of Hectic Fever.]

The pulse is small, feeble, and compressible, and the temperature rises
in the afternoon or evening to 102 or 103 F. (Fig. 11), the cheeks
becoming characteristically flushed. In the early morning the
temperature falls to normal or below it, and the patient breaks into a
profuse perspiration, which leaves him pale, weak, and exhausted. He
becomes rapidly and markedly emaciated, even although in some cases the
appetite remains good and is even voracious.

The poisons circulating in the blood produce _waxy degeneration_ in
certain viscera, notably the liver, spleen, kidneys, and intestines. The
process begins in the arterial walls, and spreads thence to the
connective-tissue structures, causing marked enlargement of the affected
organs. Albuminuria, ascites, oedema of the lower limbs, clubbing of the
fingers, and diarrhoea are among the most prominent symptoms of this
condition.

The _prognosis_ in hectic fever depends on the completeness with which
the further absorption of toxins can be prevented. In many cases this
can only be effected by an operation which provides for free drainage,
and, if possible, the removal of infected tissues. The resulting wound
is best treated by the open method. Even advanced waxy degeneration does
not contra-indicate this line of treatment, as the diseased organs
usually recover if the focus from which absorption of toxic material is
taking place is completely eradicated.

[Illustration: FIG. 12.--Chart of case of Septicaemia followed by
Pyaemia.]

#Septicaemia.#--This form of blood-poisoning is the result of the action
of pyogenic bacteria, which not only produce their toxins at the primary
seat of infection, but themselves enter the blood-stream and are carried
to other parts, where they settle and produce further effects.

_Clinical Features._--There may be an incubation period of some hours
between the infection and the first manifestation of acute septicaemia.
In such conditions as acute osteomyelitis or acute peritonitis, we see
the most typical clinical pictures of this condition. The onset is
marked by a chill, or a rigor, which may be repeated, while the
temperature rises to 103 or 104 F., although in very severe cases the
temperature may remain subnormal throughout, the virulence of the toxins
preventing reaction. It is in the general appearance of the patient and
in the condition of the pulse that we have our best guides as to the
severity of the condition. If the pulse remains firm, full, and regular,
and does not exceed 110 or even 120, while the temperature is moderately
raised, the outlook is hopeful; but when the pulse becomes small and
compressible, and reaches 130 or more, especially if at the same time
the temperature is low, a grave prognosis is indicated. The tongue is
often dry and coated with a black crust down the centre, while the sides
are red. It is a good omen when the tongue becomes moist again. Thirst
is most distressing, especially in septicaemia of intestinal origin.
Persistent vomiting of dark-brown material is often present, and
diarrhoea with blood-stained stools is not uncommon. The urine is small
in amount, and contains a large proportion of urates. As the poisons
accumulate, the respiration becomes shallow and laboured, the face of a
dull ashy grey, the nose pinched, and the skin cold and clammy.
Capillary haemorrhages sometimes take place in the skin or mucous
membranes; and in a certain proportion of cases cutaneous eruptions
simulating those of scarlet fever or measles appear, and are apt to lead
to errors in diagnosis. In other cases there is slight jaundice. The
mental state is often one of complete apathy, the patient failing to
realise the gravity of his condition; sometimes there is delirium.

The _prognosis_ is always grave, and depends on the possibility of
completely eradicating the focus of infection, and on the reserve force
the patient has to carry him over the period during which he is
eliminating the poison already circulating in his blood.

The _treatment_ is carried out on the same lines as in sapraemia, but it
is less likely to be successful owing to the organisms having entered
the circulation. When possible, the primary focus of infection should be
dealt with.

#Pyaemia# is a form of blood-poisoning characterised by the development
of secondary foci of suppuration in different parts of the body. Toxins
are thus introduced into the blood, not only at the primary seat of
infection, but also from each of these metastatic collections. Like
septicaemia, this condition is due to pyogenic bacteria, the
_streptococcus pyogenes_ being the commonest organism found. The primary
infection is usually in a wound--for example, a compound fracture--but
cases occur in which the point of entrance of the bacteria is not
discoverable. The dissemination of the organisms takes place through the
medium of infected emboli which form in a thrombosed vein in the
vicinity of the original lesion, and, breaking loose, are carried
thence in the blood-stream. These emboli lodge in the minute vessels of
the lungs, spleen, liver, kidneys, pleura, brain, synovial membranes, or
cellular tissue, and the bacteria they contain give rise to secondary
foci of suppuration. Secondary abscesses are thus formed in those parts,
and these in turn may be the starting-point of new emboli which give
rise to fresh areas of pus formation. The organs above named are the
commonest situations of pyaemic abscesses, but these may also occur in
the bone marrow, the substance of muscles, the heart and pericardium,
lymph glands, subcutaneous tissue, or, in fact, in any tissue of the
body. Organisms circulating in the blood are prone to lodge on the
valves of the heart and give rise to endocarditis.

[Illustration: FIG. 13.--Chart of Pyaemia following on Acute
Osteomyelitis.]

_Clinical Features._--Before antiseptic surgery was practised, pyaemia
was a common complication of wounds. In the present day it is not only
infinitely less common, but appears also to be of a less severe type.
Its rarity and its mildness may be related as cause and effect, because
it was formerly found that pyaemia contracted from a pyaemic patient was
more virulent than that from other sources.

In contrast with sapraemia and septicaemia, pyaemia is late of developing,
and it seldom begins within a week of the primary infection. The first
sign is a feeling of chilliness, or a violent rigor lasting for perhaps
half an hour, during which time the temperature rises to 103, 104, or
105 F. In the course of an hour it begins to fall again, and the
patient breaks into a profuse sweat. The temperature may fall several
degrees, but seldom reaches the normal. In a few days there is a second
rigor with rise of temperature, and another remission, and such attacks
may be repeated at diminishing intervals during the course of the
illness (Figs. 12 and 13). The pulse is soft, and tends to remain
abnormally rapid even when the temperature falls nearly to normal.

The face is flushed, and wears a drawn, anxious expression, and the eyes
are bright. A characteristic sweetish odour, which has been compared to
that of new-mown hay, can be detected in the breath and may pervade the
patient. The appetite is lost; there may be sickness and vomiting and
profuse diarrhoea; and the patient emaciates rapidly. The skin is
continuously hot, and has often a peculiar pungent feel. Patches of
erythema sometimes appear scattered over the body. The skin may assume a
dull sallow or earthy hue, or a bright yellow icteric tint may appear.
The conjunctivae also may be yellow. In the latter stages of the disease
the pulse becomes small and fluttering; the tongue becomes dry and
brown; sordes collect on the teeth; and a low muttering form of delirium
supervenes.

Secondary infection of the parotid gland frequently occurs, and gives
rise to a suppurative parotitis. This condition is associated with
severe pain, gradually extending from behind the angle of the jaw on to
the face. There is also swelling over the gland, and eventually
suppuration and sloughing of the gland tissue and overlying skin.

Secondary abscesses in the lymph glands, subcutaneous tissue, or joints
are often so insidious and painless in their development that they are
only discovered accidentally. When the abscess is evacuated, healing
often takes place with remarkable rapidity, and with little impairment
of function.

The general symptoms may be simulated by an attack of malaria.

_Prognosis._--The prognosis in acute pyaemia is much less hopeless than
it once was, a considerable proportion of the patients recovering. In
acute cases the disease proves fatal in ten days or a fortnight, death
being due to toxaemia. Chronic cases often run a long course, lasting for
weeks or even months, and prove fatal from exhaustion and waxy disease
following on prolonged suppuration.

_Treatment._--In such conditions as compound fractures and severe
lacerated wounds, much can be done to avert the conditions which lead to
pyaemia, by applying a Bier's constricting bandage as soon as there is
evidence of infection having taken place, or even if there is reason to
suspect that the wound is not aseptic.

If sepsis is already established, and evidence of general infection is
present, the wound should be opened up sufficiently to admit of thorough
disinfection and drainage, and the constricting bandage applied to aid
the defensive processes going on in the tissues. If these measures fail,
amputation of the limb may be the only means of preventing further
dissemination of infective material from the primary source of
infection.

Attempts have been made to interrupt the channel along which the
infective emboli spread, by ligating or resecting the main vein of the
affected part, but this is seldom feasible except in the case of the
internal jugular vein for infection of the transverse sinus.

Secondary abscesses must be aspirated or opened and drained whenever
possible.

The general treatment is conducted on the same lines as on other forms
of pyogenic infection.

CHAPTER V

ULCERATION AND ULCERS

Definitions--Clinical examination of an ulcer--The healing
sore.--Classification of ulcers--A. According to cause:
_Traumatism_, _Imperfect circulation_, _Imperfect nerve-supply_,
_Constitutional causes_--B. According to condition: _Healing_,
_Stationary_, _Spreading_.--Treatment.

The process of _ulceration_ may be defined as the molecular or cellular
death of tissue taking place on a free surface. It is essentially of the
same nature as the process of suppuration, only that the purulent
discharge, instead of collecting in a closed cavity and forming an
abscess, at once escapes on the surface.

An _ulcer_ is an open wound or sore in which there are present certain
conditions tending to prevent it undergoing the natural process of
repair. Of these, one of the most important is the presence of
pathogenic bacteria, which by their action not only prevent healing, but
so irritate and destroy the tissues as to lead to an actual increase in
the size of the sore. Interference with the nutrition of a part by oedema
or chronic venous congestion may impede healing; as may also induration
of the surrounding area, by preventing the contraction which is such an
important factor in repair. Defective innervation, such as occurs in
injuries and diseases of the spinal cord, also plays an important part
in delaying repair. In certain constitutional conditions, too--for
example, Bright's disease, diabetes, or syphilis--the vitiated state of
the tissues is an impediment to repair. Mechanical causes, such as
unsuitable dressings or ill-fitting appliances, may also act in the same
direction.

#Clinical Examination of an Ulcer.#--In examining any ulcer, we
observe--(1) Its _base_ or _floor_, noting the presence or absence of
granulations, their disposition, size, colour, vascularity, and whether
they are depressed or elevated in relation to the surrounding parts. (2)
The _discharge_ as to quantity, consistence, colour, composition, and
odour. (3) The _edges_, noting particularly whether or not the marginal
epithelium is attempting to grow over the surface; also their shape,
regularity, thickness, and whether undermined or overlapping, everted or
depressed. (4) The _surrounding tissues_, as to whether they are
congested, oedematous, inflamed, indurated, or otherwise. (5) Whether or
not there is _pain_ or tenderness in the raw surface or its
surroundings. (6) The _part of the body_ on which it occurs, because
certain ulcers have special seats of election--for example, the varicose
ulcer in the lower third of the leg, the perforating ulcer on the sole
of the foot, and so on.

#The Healing Sore.#--If a portion of skin be excised aseptically, and no
attempt made to close the wound, the raw surface left is soon covered
over with a layer of coagulated blood and lymph. In the course of a few
days this is replaced by the growth of _granulations_, which are of
uniform size, of a pinkish-red colour, and moist with a slight serous
exudate containing a few dead leucocytes. They grow until they reach the
level of the surrounding skin, and so fill the gap with a fine velvety
mass of granulation tissue. At the edges, the young epithelium may be
seen spreading in over the granulations as a fine bluish-white pellicle,
which gradually covers the sore, becoming paler in colour as it
thickens, and eventually forming the smooth, non-vascular covering of
the cicatrix. There is no pain, and the surrounding parts are healthy.

This may be used as a type with which to compare the ulcers seen at the
bedside, so that we may determine how far, and in what particulars,
these differ from the type; and that we may in addition recognise the
conditions that have to be counteracted before the characters of the
typical healing sore are assumed.

For purposes of contrast we may indicate the characters of an open sore
in which bacterial infection with pathogenic bacteria has taken place.
The layer of coagulated blood and lymph becomes liquefied and is thrown
off, and instead of granulations being formed, the tissues exposed on
the floor of the ulcer are destroyed by the bacterial toxins, with the
formation of minute sloughs and a quantity of pus.

The discharge is profuse, thin, acrid, and offensive, and consists of
pus, broken-down blood-clot, and sloughs. The edges are inflamed,
irregular, and ragged, showing no sign of growing epithelium--on the
contrary, the sore may be actually increasing in area by the
breaking-down of the tissues at its margins. The surrounding parts are
hot, red, swollen, and oedematous; and there is pain and tenderness both
in the sore itself and in the parts around.

#Classification of Ulcers.#--The nomenclature of ulcers is much involved
and gives rise to great confusion, chiefly for the reason that no one
basis of classification has been adopted. Thus some ulcers are named
according to the causes at work in producing or maintaining them--for
example, the traumatic, the septic, and the varicose ulcer; some from
the constitutional element present, as the gouty and the diabetic ulcer;
and others according to the condition in which they happen to be when
seen by the surgeon, such as the weak, the inflamed, and the callous
ulcer.

So long as we retain these names it will be impossible to find a single
basis for classification; and yet many of the terms are so descriptive
and so generally understood that it is undesirable to abolish them. We
must therefore remain content with a clinical arrangement of ulcers,--it
cannot be called a classification,--considering any given ulcer from two
points of view: first its _cause_, and second its _present condition_.
This method of studying ulcers has the practical advantage that it
furnishes us with the main indications for treatment as well as for
diagnosis: the cause must be removed, and the condition so modified as
to convert the ulcer into an aseptic healing sore.

A. #Arrangement of Ulcers according to their Cause.#--Although any given
ulcer may be due to a combination of causes, it is convenient to
describe the following groups:

_Ulcers due to Traumatism._--Traumatism in the form of a _crush_ or
_bruise_ is a frequent cause of ulcer formation, acting either by
directly destroying the skin, or by so diminishing its vitality that it
is rendered a suitable soil for bacteria. If these gain access, in the
course of a few days the damaged area of skin becomes of a greyish
colour, blebs form on it, and it undergoes necrosis, leaving an
unhealthy raw surface when the slough separates.

_Heat_ and _prolonged exposure to the Rontgen rays_ or _to radium
emanations_ act in a similar way.

The _pressure_ of improperly padded splints or other appliances may so
far interfere with the circulation of the part pressed upon, that the
skin sloughs, leaving an open sore. This is most liable to occur in
patients who suffer from some nerve lesion--such as anterior
poliomyelitis, or injury of the spinal cord or nerve-trunks.
Splint-pressure sores are usually situated over bony prominences, such
as the malleoli, the condyles of the femur or humerus, the head of the
fibula, the dorsum of the foot, or the base of the fifth metatarsal
bone. On removing the splint, the skin of the part pressed upon is found
to be of a red or pink colour, with a pale grey patch in the centre,
which eventually sloughs and leaves an ulcer. Certain forms of
_bed-sore_ are also due to prolonged pressure.